Dr. Luke Gilbert is an Associate Professor at the University of California, San Francisco and a Core Investigator at the Arc Institute of Stanford, UC Berkeley and UCSF. He received his B.S. from UCLA, Ph.D. from MIT and completed his postdoctoral training at UCSF. Dr. Gilbert was an early pioneer in repurposed CRISPR systems that are used to turn genes on (CRISPRa) and off (CRISPRi). More recently, the Gilbert lab has developed new strategies for editing heritable epigenetic memories (CRISPRoff/on). Dr. Gilbert co-founded Chroma Medicine in 2020 with the goal of seeing single dose epigenetic editors established as a new type of therapeutic for treatment of human diseases such as Hepatitis B. The Gilbert lab has also created several Cas9 and Cas12 based functional genomics platforms for systematically mapping human gene function and genetic interactions at very large scales or at single cell resolution. Medically, the Gilbert lab is focusing on using CRISPR functional genomics expertise to tackle big problems in cancer biology with a special focus on prostate cancer. Dr. Gilbert’s research has been recognized by a NIH Director’s New Innovator Award, a Pew-Stewart Scholar for Cancer Research Award, and the AAAS Martin and Rose Wachtel Cancer Research Award.